Two case reports of continued progression of chronic ocular graft-versus-host disease without concurrent systemic comorbidities treated by amniotic membrane transplantation

Abstract Background Chronic ocular graft-versus-host disease (oGVHD) is an comorbidity of (GVHD) that usually occurs concurrently with systemic manifestations. Failure to detect and treat oGVHD in its early stages may lead progression signs symptoms leading refractory conventional treatment. Case presentation We report the clinical course a 19-year-old male 59-year-old female severe progressive chronic without concurrent (cGVHD). Although their conditions had been stable, both suffered from were referred our clinic. Both cases exhibited marked improvement conjunctival inflammation fibrotic changes after amniotic membrane transplantation (AMT). underwent keratoplasty eventually stabilize surface improve visual function. Conclusions reported outcomes 2 comorbidities treated AMT. The clinician should be aware cGVHD persist target organs even absence following seemingly successful A multidisciplinary team approach essential detection therapeutic intervention for oGVHD.